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Clinical Research Articles

This section is purely for educational purpose and not for use in clinical decision-making. 

 

Active research on TMS is ongoing and new information and data are being published by academic facilities on a consistent basis. The list of clinical research articles below is a small sample of useful academic resources discussing various scientific advancements on the understanding and application of TMS.

  1. Avery, D. H., Zarkowski, P., Krashin, D., Rho, W.-K., Wajdik, C., Joesch, J. M., et al. (2015). Transcranial magnetic stimulation in the treatment of chronic widespread pain: a randomized controlled study. The Journal of ECT, 31(1), 57–66.

  2. Avery, D.H., Isenberg, K.E., et al. (2008) Transcranial Magnetic Stimulation in the acute treatment of major depressive disorder: Clinical response in an open-label extension trial. J Clin Psychiatry 69:3, 441-451.

  3. Bashir, S., Perez, J. M., Horvath, J. C., Pena-Gomez, C., Vernet, M., Capia, A., et al. (2014). Differential effects of motor cortical excitability and plasticity in young and old individuals: a Transcranial Magnetic Stimulation (TMS) study. Frontiers in Aging Neuroscience, 6(38), 111. 

  4. Best, S. R. D., & Griffin, B. (2015). Combination therapy utilizing ketamine and transcranial magnetic stimulation for treatment-resistant depression: a case report. The International Journal of Neuroscience, 125(3), 232–234. 

  5. Borckardt, J. J., Reeves, S. T., Frohman, H., Madan, A., Jensen, M. P., Patterson, D., et al. (2011). Fast left prefrontal rTMS acutely suppresses analgesic effects of perceived controllability on the emotional component of pain experience. Pain, 152(1), 182–187. 

  6. Borckardt, J. J., Smith, A. R., Reeves, S. T., Madan, A., Shelley, N., Branham, R., et al. (2009). A pilot study investigating the effects of fast left prefrontal rTMS on chronic neuropathic pain. Pain Medicine (Malden, Mass.), 10(5), 840–849. 

  7. Casanova, M. F., Baruth, J. M., El-Baz, A., Tasman, A., Sears, L., & Sokhadze, E. (2012). Repetitive Transcranial Magnetic Stimulation (rTMS) Modulates Event-Related Potential (ERP) Indices of Attention in Autism. Translational Neuroscience, 3(2), 170–180. 

  8. Casanova, M. F., Hensley, M. K., Sokhadze, E. M., El-Baz, A. S., Wang, Y., Li, X., & Sears, L. (2014). Effects of weekly low-frequency rTMS on autonomic measures in children with autism spectrum disorder. Frontiers in Human Neuroscience, 8, 851. 

  9. Carpenter, L.L., Janicak, P. G., et al. (2012) Transcranial Magnetic Stimulation (TMS) for Major Depression: A Multisite, Naturalistic, Observational Study of Acute Treatment Outcomes in Clinical Practice. Depression and Anxiety 29:587–596.

  10. Chen, J., Zhou, C., Wu, B., Wang, Y., Li, Q., Wei, Y., et al. (2013). Left versus right repetitive transcranial magnetic stimulation in treating major depression: a meta-analysis of randomised controlled trials. Psychiatry Research, 210(3), 1260–1264. 

  11. Cohen, D. A., Freitas, C., Tormos, J. M., Oberman, L., Eldaief, M., & Pascual-Leone, A. (2010). Enhancing plasticity through repeated rTMS sessions: the benefits of a night of sleep. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 121(12), 2159–2164. 

  12. Croarkin, P. E., Wall, C. A., & Lee, J. (2011). Applications of transcranial magnetic stimulation (TMS) in child and adolescent psychiatry. International Review of Psychiatry (Abingdon, England), 23(5), 445–453. 

  13. D, K. C. M. (2015). A Retrospective Analysis of Right Dorsolateral Prefrontal Cortex (RDLPFC) Transcranial Magnetic Stimulation Treatments for Patients Showing Symptoms of Anxiety and/or Irritability. Brain Stimulation, 8(5), e2., 

  14. T., Avery, D. H., & Russo, J. (2007). Within-session mood changes from TMS in depressed patients. The Journal of Neuropsychiatry and Clinical Neurosciences, 19(4), 458–463. 

  15. Demirtas-Tatlidede, A., Vahabzadeh-Hagh, A. M., & Pascual-Leone, A. (2013). Can noninvasive brain stimulation enhance cognition in neuropsychiatric disorders? Neuropharmacology, 64, 566–578. 

  16. Demitrack, M.A. (2010) Transcranial Magnetic Stimulation for the Treatment of Major Depression Clinical, Economic, and Practical Issues: Part 1. Psychopharm Review 45(4).

  17. Demitrack, M.A. (2010) Transcranial Magnetic Stimulation for the Treatment of Major Depression Clinical, Economic, and Practical Issues: Part 2. Psychopharm Review 45(8).

  18. Demitrack, M.A., Thase, M. (2009) Clinical Significance of Transcranial Magnetic Stimulation (TMS) in the Treatment of Pharmacoresistant Depression: Synthesis of Recent Data. Psychopharmacology Bulletin 42(2): 5-38.

  19. Desarkar, P., Rajji, T. K., Ameis, S. H., & Daskalakis, Z. J. (2015a). Assessing and Stabilizing Aberrant Neuroplasticity in Autism Spectrum Disorder: The Potential Role of Transcranial Magnetic Stimulation. Frontiers in Psychiatry, 6, 124. 

  20. Desarkar, P., Rajji, T. K., Ameis, S. H., & Daskalakis, Z. J. (2015b). Assessing and Stabilizing Aberrant Neuroplasticity in Autism Spectrum Disorder: The Potential Role of Transcranial Magnetic Stimulation. Frontiers in Psychiatry, 6(5), 124. 

  21. Diefenbach, G. J., Bragdon, L., & Goethe, J. W. (2013). Treating anxious depression using repetitive transcranial magnetic stimulation. Journal of Affective Disorders, 151(1), 365–368. 

  22. Dlabac-de Lange, J. J., Liemburg, E. J., Bais, L., Renken, R. J., Knegtering, H., & Aleman, A. (2015). Effect of rTMS on brain activation in schizophrenia with negative symptoms: A proof-of-principle study. Schizophrenia Research, 168(1-2), 475–482. 

  23. Drumond Marra, H. L., Myczkowski, M. L., Maia Memória, C., Arnaut, D., Leite Ribeiro, P., Sardinha Mansur, C. G., et al. (2015). Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study. Behavioural Neurology, 2015(1), 287843–13. 

  24. Dunner, D. L., Aaronson, S. T., Sackeim, H. A., Janicak, P. G., Carpenter, L. L., Boyadjis, T., et al. (2014). A multisite, naturalistic, observational study of transcranial magnetic stimulation for patients with pharmacoresistant major depressive disorder: durability of benefit over a 1-year follow-up period. The Journal of Clinical Psychiatry, 75(12), 1394–1401. 

  25. Enticott, P. G., Fitzgibbon, B. M., Kennedy, H. A., Arnold, S. L., Elliot, D., Peachey, A., et al. (2014). A double-blind, randomized trial of deep repetitive transcranial magnetic stimulation (rTMS) for autism spectrum disorder. Brain Stimulation, 7(2), 206–211. 

  26. ENTICOTT, P. G., Kennedy, H. A., RINEHART, N. J., TONGE, B. J., BRADSHAW, J. L., & Fitzgerald, P. B. (2013). GABAergic activity in autism spectrum disorders: an investigation of cortical inhibition via transcranial magnetic stimulation. Neuropharmacology, 68, 202–209. 

  27. ENTICOTT, P. G., RINEHART, N. J., TONGE, B. J., BRADSHAW, J. L., & Fitzgerald, P. B. (2010). A preliminary transcranial magnetic stimulation study of cortical inhibition and excitability in high-functioning autism and Asperger disorder. Developmental Medicine and Child Neurology, 52(8), e179–83. 

  28. Fitzgerald, P. B., Brown, T. L., Marston, N. A. U., Daskalakis, Z. J., De Castella, A., & Kulkarni, J. (2003). Transcranial magnetic stimulation in the treatment of depression: a double-blind, placebo-controlled trial. Archives of General Psychiatry, 60(10), 1002–1008. 

  29. George, M. S., Lisanby, S. H., Avery, D., McDonald, W. M., Durkalski, V., Pavlicova, M., et al. (2010). Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial. Archives of General Psychiatry, 67(5), 507–516. 

  30. Haghighi, M., Shayganfard, M., Jahangard, L., Ahmadpanah, M., Bajoghli, H., Pirdehghan, A., et al. (2015). Repetitive Transcranial Magnetic Stimulation (rTMS) improves symptoms and reduces clinical illness in patients suffering from OCD - Results from a single-blind, randomized clinical trial with sham cross-over condition. Journal of Psychiatric Research, 68, 238–244. 

  31. Helfrich, C., Pierau, S. S., Freitag, C. M., Roeper, J., Ziemann, U., & Bender, S. (2012). Monitoring cortical excitability during repetitive transcranial magnetic stimulation in children with ADHD: a single-blind, sham-controlled TMS-EEG study. PloS One, 7(11), e50073. 

  32. Hoffman, R. E., Hawkins, K. A., Gueorguieva, R., Boutros, N. N., Rachid, F., Carroll, K., & Krystal, J. H. (2003). Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations. Archives of General Psychiatry, 60(1), 49–56.

  33. Janicak, PG, Dunner, DL, Aaronson, ST, Carpenter, LL, Boyadjis, TA, Brock, DG, Cook, IA, Lanocha, K, Solvason, HB, Bonneh-Barkay, D, Demitrack, MA. (2013) Transcranial Magnetic Stimulation (TMS) for Major Depression: A Multisite, Naturalistic, Observational Study of Quality of Life Outcome Measures in Clinical Practice, CNS Spectrums, August: 1- 11.

  34. Janicak, P.G., Nahas, Z, et al. (2010) Durability of clinical benefit with transcranial magnetic stimulation (TMS) in the treatment of pharmacoresistant major depression: assessment of relapse during a 6-month, multisite, open-label study. Brain Stimulation 3(4): 187-199.

  35. Janicak, P.G., O’Reardon, J.P., et al. (2008) Transcranial Magnetic Stimulation in the treatment of major depression: A comprehensive summary of safety experience from acute exposure, extended exposure, and during reintroduction treatment. Journal of Clinical Psychiatry 69, 222-232.

  36. Johnson, K. A., Baig, M., Ramsey, D., Lisanby, S. H., Avery, D., McDonald, W. M., et al. (2013). Prefrontal rTMS for treating depression: location and intensity results from the OPT-TMS multi-site clinical trial. Brain Stimulation, 6(2), 108–117. 

  37. Kedzior, K. K., Gellersen, H. M., Brachetti, A. K., & Berlim, M. T. (2015). Deep transcranial magnetic stimulation (DTMS) in the treatment of major depression: An exploratory systematic review and meta-analysis. Journal of Affective Disorders, 187, 73–83. http://doi.org/10.1016/j.jad.2015.08.033

  38. Kleim, J. A., Kleim, E. D., & Cramer, S. C. (2007). Systematic assessment of training-induced changes in corticospinal output to hand using frameless stereotaxic transcranial magnetic stimulation. Nature Protocols, 2(7), 1675–1684. 

  39. Klein, M. M., Treister, R., Raij, T., Pascual-Leone, A., Park, L., Nurmikko, T., et al. (2015). Transcranial magnetic stimulation of the brain: guidelines for pain treatment research. Pain, 156(9), 1601–1614. 

  40. Li, X., Fryml, L., Rodriguez, J. J., Taylor, J., Borckardt, J. J., Short, B., et al. (2014). Safe Management of a Bipolar Depressed Patient With Prefrontal Repetitive Transcranial Magnetic Stimulation (rTMS) Over 7 Years and >2 Million Stimuli. Brain Stimulation, 7(6), 919–921. 

  41. Lin, K.-L., & Pascual-Leone, A. (2002). Transcranial magnetic stimulation and its applications in children. Chang Gung Medical Journal, 25(7), 424–436.

  42. Lisanby, S. H., Husain, M. M., Rosenquist, P. B., Maixner, D., Gutierrez, R., Krystal, A., et al. (2009). Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial. Neuropsychopharmacology, 34(2), 522–534. 

  43. Mantovani, A, Pavlicova, M, Avery, D, Nahas, Z, McDonald, WM, Wajdik, CD, Holtzheimer, PE, George, MS, Sackeim, HA, Lisanby, SH. Long-Term Efficacy of Repeated Daily Prefrontal Transcranial Magnetic Stimulation (TMS) in Treatment-Resistant Depression. (2012) Depression and Anxiety, 00:1-8.

  44. McDonald WM, Durkalski V, Ball ER, Holtzheimer PE, Pavlicova M, Lisanby SH, Avery D, Anderson BS, Nahas Z, Zarkowski P, Sackeim HA, George MS (2011) Improving the Antidepressant Efficacy of Transcranial Magnetic Stimulation: Maximizing the Number of Stimulations and Treatment Location in Treatment-Resistant Depression. Depress Anxiety. Nov; 28(11):973-80.

  45. “Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults. Comparative Effectiveness Review No. 33”. Agency for Healthcare and Quality. September 2011. Available at: http://www.effectivehealthcare.ahrq.gov/search-for-guides-reviews-and- reports/?pageaction=displayproduct&productID=792

  46. “Nonpharmacologic Interventions for Treatment-Resistant Depression: Supplementary Data and Analyses to the Comparative Effectiveness Review of the Agency for Healthcare Research and Quality”. New England Comparative Effectiveness Public Advisory Council (CEPAC). December 2011. Available at: http://cepac.icer-review.org/wp- content/uploads/2011/04/Final-Report-TRD_FINAL2.pdf

  47. O'Reardon, J.P., Solvason, H.B., et al. (2007) Efficacy and safety of Transcranial Magnetic Stimulation in the acute treatment of major depression: A multisite randomized controlled trial. Biol Psychiatry, 62:1208-1216.

  48. Rosenquist P.B., et al., (2013) Left dorsolateral prefrontal transcranial magnetic stimulation (TMS): Sleep factor changes during treatment in patients with pharmacoresistant major depressive disorder, Psychiatry Res. 30;205 (1-2):67-73

  49. Simpson, K. N., Welch, M. J., et al. (2009) Cost Effectiveness of Transcranial Magnetic Stimulation in the Treatment of Major Depression: a Health Economics Analysis. Adv. Ther. 26(3):346-68.

  50. Solvason HB, et al. (2014) Improvement in Quality of Life With Left Prefrontal Transcranial Magnetic Stimulation in Patients With Pharmacoresistant Major Depression: Acute and Six Month Outcomes. Brain Stimul. 7:219-225.

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